Cooperation by different subjects (ICT, BAFS, Chinese Language and Mathematics) teachers, we built a curriculum to nurture empathy and creativity of students in Innovative Interdisciplinary "Start Me Up" Programme. The curriculum focuses on S.4 students, including positive education, design thinking and entrepreneurial spirits.Teachers used social capitals such as partnership with social enterprise for students to have authentic experience using PBL approach. Students are asked to split into different small groups and built a project using design thinking. The scenario for projects are about school and social enterprise. Finally, students made a prototype and pitching to judges and guests. The core value of the curriculum includes: - Innovative Interdisciplinary "Start Me Up" Programme: To nurture empathy and creativity of students - To pursue their dreams and interests, nurture the “entrepreneurial spirits” - To build up the students about caring for the community, building the empathy. Some students awarded the championship of an entrepreneur competition 2019.